Supporting interdisciplinary approaches to cancer research. The CSBC initiative supports research that investigates the challenges of complexity in basic and translational cancer research through the explicit combination of experimental biology and computational modeling, multi-dimensional data analysis, and systems engineering.
Arizona Cancer and Evolution Center
The mission of the Arizona Cancer and Evolution Center (ACE) is to advance our fundamental understanding of cancer and its clinical management through the development and application of evolutionary and ecological models to cancer biology.
An Integrated Systems Approach for Incompletely Penetrant Onco-Phenotypes
We aim to identify key molecular networks upstream of incompletely penetrant phenotypes to better understand the transition from tumor initiation to progression and to develop more effective therapeutic interventions.
-
Tumor-Immune
-
Heterogeneity / Evolution
-
Drug Resistance / Sensitivity
-
Metastasis
-
Micro Environment
Publications
- Robust cell detection and segmentation for image cytometry reveal Th17 cell heterogeneity. Takahiro Tsujikawa, Guillaume Thibault, Vahid Azimi, Sam Sivagnanam, Grace Banik, Casey Means, Rie Kawashima, Daniel R. Clayburgh, Joe W. Gray, Lisa M. Coussens, Young Hwan Chang, Cytometry: Part A, 2019
- Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting. Langer, E.M., Allen-Petersen, B.L., King, S.M., Kendsersky, N.D., Turnidge, M.A., Kuziel, G.M., Riggers, R., Samatham, R., Amery, T.S., Jacques, S.L., Sheppard, B.C., Korkola, J.E., Muschler, J.L., Thibault, G., Chang, Y.H., Gray, J.W., Presnell S.C., Nguyen, D.G., Sears, R.C. Cell reports, 2019, 26(3), pp.608-623.