Supporting interdisciplinary approaches to cancer research. The CSBC initiative supports research that investigates the challenges of complexity in basic and translational cancer research through the explicit combination of experimental biology and computational modeling, multi-dimensional data analysis, and systems engineering.
Arizona Cancer and Evolution Center
The mission of the Arizona Cancer and Evolution Center (ACE) is to advance our fundamental understanding of cancer and its clinical management through the development and application of evolutionary and ecological models to cancer biology.
An Integrated Systems Approach for Incompletely Penetrant Onco-Phenotypes
We aim to identify key molecular networks upstream of incompletely penetrant phenotypes to better understand the transition from tumor initiation to progression and to develop more effective therapeutic interventions.
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Tumor-Immune
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Heterogeneity / Evolution
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Drug Resistance / Sensitivity
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Metastasis
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Micro Environment
Publications
- HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice.. Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E992-E1001. doi: 10.1073/pnas.1718009115. Epub 2018 Jan 16.
- Comparing side chain packing in soluble proteins, protein-protein interfaces, and transmembrane proteins.Gaines JC, Acebes S, Virrueta A, Butler M, Regan L, O’Hern CS Proteins. 2018 May;86(5):581-591. doi: 10.1002/prot.25479. Epub 2018 Feb 26.. Gaines JC, Acebes S, Virrueta A, Butler M, Regan L, O'Hern CS Proteins. 2018 May;86(5):581-591. doi: 10.1002/prot.25479. Epub 2018 Feb 26.