Dr. Marian Waterman: Investigating Non-Genetic Heterogeneity in Colon Cancer

Marian Waterman, Ph.D., a CSBC investigator at the University of California, Irvine (UC Irvine), began her career as a biochemist using reductionist approaches to investigate gene transcription. As a young investigator, she moved into cancer biology and studied the role of a transcription factor family in colon cancer. Later, the focus in her lab shifted as she realized that a systems biology approach could take data from reductionist experiments and place it in a larger context. Now, Marian integrates mathematical modeling with experimentation to study tumor heterogeneity.