Dr. Andrea Califano Investigates Regulatory Mechanisms in Cancer Using Computational Algorithms and Biological Experiments
Columbia University CSBC Investigator Andrea Califano, Ph.D., studies proteins that control cellular networks, known as master regulators, and their role in cancer progression.
As a post-doc in physics at MIT, he was excited by the emerging areas of artificial intelligence and machine vision. Then, he worked for IBM, first developing algorithms for pattern discovery and then applying mathematical models to biological data. However, according to him, he transitioned to academic systems biology research because, “I wanted to put my money where my mouth was and have a chance to experimentally validate my computational predictions.”
Dr. Diana Murray Encourages Students to Consider Careers in Cancer Systems Biology
Diana Murray, Ph.D., is a CSBC Investigator and the Outreach Core Leader at the Center for Cancer Systems Therapeutics (CaST) of Columbia University.
Along with computational biology investigations, Dr. Murray helps public school and post-baccalaureate students learn about career paths in basic research. She wants to give young people the chance to experience scientific studies in a multi-disciplinary field that integrates diverse interests.
She likes studying science and riding a motorcycle for similar reasons: “Both tasks are challenging and require deep concentration.”
Dr. Joe Gray: A Nuclear Physicist Who Studies Tumor Heterogeneity
Joe Gray, Ph.D., a CSBC Investigator at Oregon Health and Science University (OHSU), views systems biology as the application of experimental and computational tools to understand and predict the behavior of biological systems.
His lab is developing tools, including molecular profiling and multiscale imaging technologies, to explore the components and multiscale organization of cancer systems. Using these approaches, he wants to find better ways to control and treat cancer.
Dr. Douglas Lauffenburger Investigates Cancer Biology from an Engineering Perspective
Doug Lauffenburger, Ph.D., a CSBC Investigator at the Massachusetts Institute of Technology (MIT), has been integrating engineering and computation with biology throughout his long career. When describing his research journey, he said, “Systems biology was established and coined around 2000, but I didn’t see it as anything different from what I had already been doing for 20 years.”
Dr. Nevan Krogan: Generating a Map of Biological Networks in a Cancer Cell
Dr. Nevan Krogan, a CSBC Investigator and Director of the Quantitative Biosciences Institute at the University of California, San Francisco (UCSF), develops tools to study quantitative changes in biomolecules.
Dr. Trey Ideker: Mapping the Circuitry of a Cancer Cell
Trey Ideker, Ph.D., a CSBC Investigator at the University of California, San Diego (UCSD), is working to map the circuits of a cancer cell.
After training in electrical engineering, he found himself, like many other engineering and computer science graduates, working in the defense sector. However, according to Dr. Ideker, “the fact that I was facilitating mass destruction didn’t sit well on my conscience, so I knew that I needed to find a different career.”
Dr. Sylvia Plevritis Engineers Analytical Approaches to Understand Cancer Metastasis
Sylvia Plevritis, Ph.D., a CSBC Investigator at Stanford University, develops computational tools to analyze genomic and imaging data related to cancer metastasis, the progressive spread of cancer cells from an initial tumor to another part of the body.
Dr. Mark Lemmon Brings Biochemistry Expertise to Cancer Systems Biology
Mark Lemmon, Ph.D., a CSBC Investigator at Yale University, is a biochemist who examines molecular mechanisms and integrated networks in cancer. In this interview, he discusses research collaborations, the application of systems approaches for cancer research, and emerging areas for cancer systems biology.
Dr. Andrea Bild Enjoys the Challenging Terrain of Cancer Systems Biology
CSBC Investigator Andrea Bild, Ph.D., is a Professor in the Division of Molecular Pharmacology at City of Hope Medical Center in Duarte, CA. She is an avid hiker who has trekked up mountains in Utah and Colorado to admire the beauty of nature. Similarly, as a scientist and cancer researcher, she has set out on a journey to understand the complex landscape of cancer.
Dr. Ellen Langer Differentiated from a Cell Biologist to an Expert in Tumor Heterogeneity
Ellen Langer, Ph.D., a CSBC junior investigator at Oregon Health and Science University (OHSU), trained as a cell biologist and studied cellular plasticity at Washington University in St. Louis and the University of Utah. This work led to her current studies examining breast cancer cell phenotypes using systems biology approaches.
Dr. Nathan Reticker-Flynn Follows the Beat of Biological Systems in Cancer
There are many similarities between science and music, including quantitative patterns within elaborate compositions. In this interview, Nathan discusses his views on systems biology and its application to understanding cancer metastasis and immunotherapy.
Dr. Scott R. Manalis Uses Physics and Engineering to Study Cancer Cells
Scott Manalis, Ph.D., a CSBC Investigator at the Massachusetts Institute of Technology (MIT), has always been interested in coming up with new types of measurements and ways to push the limits of quantitative approaches. His enthusiasm for using a wide range of analytical skills to solve complex problems led him to study Physics at the University of California, Santa Barbara and Stanford University.
Dr. Christina Leslie: Solving Cancer Biology Questions with Computational Models
Christina Leslie, Ph.D., a CSBC investigator at Memorial Sloan Kettering, trained as a mathematician in differential geometry and Lie theory. However, after graduate school, she moved into computational biology and cancer research.
In this interview, she describes her career path, systems biology approaches, and her recent findings related to immune cell heterogeneity in cancer.